LQB581 Biomolecular Control Systems
To view more information for this unit, select Unit Outline from the list below. Please note the teaching period for which the Unit Outline is relevant.
| Unit code: | LQB581 |
|---|---|
| Prerequisite(s): | LQB381 and LQB481 |
| Credit points: | 12 |
| Timetable | Details in HiQ, if available |
| Availabilities |
|
| CSP student contribution | $1,164 |
| Domestic tuition unit fee | $4,968 |
| International unit fee | $6,216 |
Unit Outline: Semester 1 2025, Gardens Point, Internal
| Unit code: | LQB581 |
|---|---|
| Credit points: | 12 |
| Pre-requisite: | LQB381 and LQB481 |
| Coordinator: | Perry Hartfield | p.hartfield@qut.edu.au |
Overview
This unit extends the principles of enzyme structure and function, and metabolic regulation, using several model systems. It develops an advanced understanding of basic theoretical and practical aspects of metabolic systems and biomolecular signalling pathways, and the integration and regulation of cellular responses to external stimuli. Through coverage of these principles you will further develop your knowledge, practical expertise and research skills in preparation for pursuing career opportunities relating to biochemistry or allied professions in biomedical science.
Learning Outcomes
On successful completion of this unit you will be able to:
- Analyse and evaluate protein and enzymatic networks and systems in the context of thermodynamics and energetics, biochemical function and regulatory control mechanisms.
- Compare and contrast the relationships between metabolic pathways and their regulation and discuss them critically.
- Apply your understanding of complex biomolecular systems and pathways to biochemical and biomedical problems in health and disease.
- Demonstrate practical competency in the laboratory through the analysis, interpretation and reporting of experimental data associated with analytical approaches in practical biomolecular science.
Content
The content in this unit includes:
- Enzyme biochemistry: Energetics and thermodynamics, enzyme structure, mechanisms of enzyme action; mechanisms of enzyme inhibition; illustrative examples and model studies.
- Regulation and control of metabolism in health and disease: Fatty acid metabolism, Cholesterol Metabolism and Complex Lipid Metabolism, including lipid delivery systems and lipoprotein metabolism, the roles of subcellular compartments in metabolism, and the principles of metabolic control.
- Hormone and hormone receptor systems in metabolic control, signalling systems and their regulation: modes of regulation by hormones - types of receptors and receptor signalling systems; second messengers and signalling enzyme cascades; regulation of hormone-receptor coupling and intracellular signalling theory using model systems; role of aberrant signalling in disease; and an introduction to metabolomics.
Learning Approaches
The unit is presented as online lectures each week and a combination of either practical sessions or case-based learning sessions each week. The practical laboratory sessions include formative tutorial-type discussion and opportunity for demonstration of data analysis and feedback on performance. Both the practical sessions and tutorials are delivered using small group and individual instruction on theoretical and data-handling techniques. Practical exercises instruct you to prepare adequately for laboratory work, to record data accurately, validate and verify results and to be competent in complex manipulations and calculations that are common in research work and consistent with the development of best professional practice. You will be encouraged to think critically about the way your data is gathered and analysed, and to develop the skills of best-method approach to problem solving. This approach is supported by formative sets of problems demonstrating different concepts that you are able to work through at your own pace. Further, you are referred to appropriate Web sites for additional and current information.
Feedback on Learning and Assessment
Feedback will be available on your continuous assessment and progress.
This unit has been evaluated affirmatively through previous learning experience surveys and student evaluation.
Assessment
Overview
Continuous assessment items will be distributed in a non-overlapping pattern throughout the semester. Formative feedback on your learning and understanding is provided through the regular tutorial and laboratory exercises. Summative assessment is by a mixture of continuous assessment throughout the semester and examination.
Unit Grading Scheme
7- point scale
Assessment Tasks
Assessment: Problem Solving Task
Problem-based and case-based learning exercises that integrate central theory topics with practical and technological applications delivered through tutorials.
This assignment is eligible for the 48-hour late submission period and assignment extensions.
Assessment: Report
Practical laboratory assessment based on formal reporting of laboratory exercises. This report will conform to the organisational structure for a standard scientific journal article.
This assignment is eligible for the 48-hour late submission period and assignment extensions.
Assessment: Examination
A theory examination consisting of a range of question types including short answer and essay questions. Formative preparation and evaluation of model answers and reasoning will be provided to assist student learning.
Academic Integrity
Academic integrity is a commitment to undertaking academic work and assessment in a manner that is ethical, fair, honest, respectful and accountable.
The Academic Integrity Policy sets out the range of conduct that can be a failure to maintain the standards of academic integrity. This includes, cheating in exams, plagiarism, self-plagiarism, collusion and contract cheating. It also includes providing fraudulent or altered documentation in support of an academic concession application, for example an assignment extension or a deferred exam.
You are encouraged to make use of QUT’s learning support services, resources and tools to assure the academic integrity of your assessment. This includes the use of text matching software that may be available to assist with self-assessing your academic integrity as part of the assessment submission process.
Breaching QUT’s Academic Integrity Policy or engaging in conduct that may defeat or compromise the purpose of assessment can lead to a finding of student misconduct (Code of Conduct – Student) and result in the imposition of penalties under the Management of Student Misconduct Policy, ranging from a grade reduction to exclusion from QUT.
Requirements to Study
Costs
Cost of lab gowns and safety protection glasses are the student's responsibility.
Resources
Advanced References:
Additional learning resources (recent reviews and journal articles) are detailed on the Canvas site for this unit.
Resource Materials
Recommended text(s)
Berg, J. M., Gatto, J. H., Tymoczko, J. L. and Stryer, L. 2023. Biochemistry. Tenth edition, Macmillan Learning.
Nelson D.L, Cox, M. M., and Lehninger A. L. 2021. Lehninger Principles of Biochemistry. Edited by Aaron A. Hoskins. Eighth edition. New York, NY: W.H. Freeman and Company.
Reference book(s)
Advanced References:
Additional learning resources (recent reviews and journal articles) are detailed on the Canvas site for this unit.
Safety and protective equipment
- Laboratory Gown - Rear fastening 100% cotton or polyester/cotton mix
- Safety eye protection glasses - selected and used in accordance with Australian Safety Standards
- Fully enclosed non-slip shoes
Risk Assessment Statement
This unit includes a laboratory component. In order that you become proficient in necessary practical skills, you will be trained in the handling of equipment, materials and specimens normally associated with this discipline. You are required to view a Health & Safety Induction video and complete an online health and safety quiz prior to being permitted into the laboratory, to access please follow this link Health & Safety Induction. A passing score of 10/10 is required and will be checked prior to entry to the first laboratory session. You may repeat the quiz until this score is achieved. You are also referred to the Faculty of Health's Health & Safety Web Site for further information.
If you have an underlying health condition you are encouraged to consult the lecturer in charge of the unit, as you may be required to take additional precautions on occasions.
Course Learning Outcomes
This unit is designed to support your development of the following course/study area learning outcomes.LS40 Bachelor of Biomedical Science
- Critically review, analyse and synthesise foundational knowledge in a broad range of biomedical discipline areas and in depth theoretical, technical and practical knowledge in specialised discipline areas.
Relates to: Problem Solving Task, Report, Examination - Demonstrate the cognitive skills required to find solutions to scientific problems.
Relates to: Problem Solving Task, Report, Examination - Contribute effectively to biomedical projects, either as an individual or as a member of a team and demonstrate professional behaviour.
Relates to: Problem Solving Task - Apply knowledge and skills to rapidly source, critically analyse and communicate biomedical science information using appropriate technologies.
Relates to: Report