LQB581 Biomolecular Control Systems

Unit Outline: Semester 1 2024, Gardens Point, Internal

Overview

This unit extends the principles of enzyme structure and function, and metabolic regulation, using several model systems. It develops an advanced understanding of basic theoretical and practical aspects of metabolic systems and biomolecular signalling pathways, and the integration and regulation of cellular responses to external stimuli. Through coverage of these principles you will further develop your knowledge, practical expertise and research skills in preparation for pursuing career opportunities relating to biochemistry or allied professions in biomedical science.

Learning Outcomes

On successful completion of this unit you will be able to:

1. Analyse and evaluate protein and enzymatic networks and systems in the context of thermodynamics and energetics, biochemical function and regulatory control mechanisms.
2. Compare and contrast the relationships between metabolic pathways and their regulation and discuss them critically.
3. Apply your understanding of complex biomolecular systems and pathways to biochemical and biomedical problems in health and disease.
4. Demonstrate practical competency in the biochemical laboratory through the analysis, interpretation and reporting of experimental data associated with analytical approaches in practical biochemistry and biomolecular science.

Content

Learning Approaches

The unit is presented as a two-hour lecture each week and a combination of either three-hour practical sessions or two hour case-based learning sessions each week. The practical laboratory sessions include formative tutorial-type discussion and opportunity for demonstration of data analysis and feedback on performance. Both the practical sessions and tutorials are delivered using small group and individual instruction on theoretical and data-handling techniques. Practical exercises are more complex than in second year level units, and instruct you to prepare adequately for laboratory work, to record data accurately, validate and verify results and to be competent in complex manipulations and calculations that are common in research work and consistent with the development of best professional practice. You will be encouraged to think critically about the way your data is gathered and analysed, and to develop the skills of best-method approach to problem solving. This approach is supported by formative sets of problems demonstrating different concepts that you are able to work through at your own pace. Further, you are referred to appropriate Web sites for additional and current information.

Feedback on Learning and Assessment

Feedback will be available on your continuous assessment and progress.

This unit has been evaluated affirmatively through previous learning experience surveys and student evaluation.

Assessment

Overview

Continuous assessment items will be distributed in a non-overlapping pattern throughout the semester. Formative feedback on your learning and understanding is provided through the regular tutorial and laboratory exercises. Summative assessment is by a mixture of continuous assessment throughout the semester and examination.

Unit Grading Scheme

7- point scale

Assessment Tasks

Assessment: Problem Solving Task

Problem-based and case-based learning exercises that integrate central theory topics with practical and technological applications delivered through tutorials.

This is an assignment for the purposes of an extension.

Assessment: Practical Reports

Practical laboratory assessment based on formal reporting of laboratory exercises.

This is an assignment for the purposes of an extension.

Assessment: Examination

A theory examination consisting of a range of question types including short answer and essay questions. Formative preparation and evaluation of model answers and reasoning will be provided to assist student learning.

Academic Integrity

Students are expected to engage in learning and assessment at QUT with honesty, transparency and fairness. Maintaining academic integrity means upholding these principles and demonstrating valuable professional capabilities based on ethical foundations.

Failure to maintain academic integrity can take many forms. It includes cheating in examinations, plagiarism, self-plagiarism, collusion, and submitting an assessment item completed by another person (e.g. contract cheating). It can also include providing your assessment to another entity, such as to a person or website.

You are encouraged to make use of QUT’s learning support services, resources and tools to assure the academic integrity of your assessment. This includes the use of text matching software that may be available to assist with self-assessing your academic integrity as part of the assessment submission process.

Further details of QUT’s approach to academic integrity are outlined in the Academic integrity policy and the Student Code of Conduct. Breaching QUT’s Academic integrity policy is regarded as student misconduct and can lead to the imposition of penalties ranging from a grade reduction to exclusion from QUT.

Requirements to Study

Costs

Cost of lab gowns and safety protection glasses are the student's responsibility.

Resources

Resource Materials

Recommended text(s)

Berg JM, Tymoczko JL, Stryer L. Biochemistry. 8th edition: WH Freeman; 2015.

Berg JM, Tymoczko JL, Stryer L. Biochemistry. 8th edition: WH Freeman; 2015.

Choose from one (or a combination) of the following. Each text is excellent, with different author perspectives, depending mainly on their research and teaching backgrounds.

Devlin TM. Textbook of Biochemistry with Clinical Correlations. 7th edition: John Wiley & Sons; 2011. (Emphasis is on human metabolism and clinical applications)

Nelson DL, Cox, MM, Lehninger AL. Lehninger Principles of Biochemistry. 7th edition: W.H. Freeman; 2017.

Reference book(s)

Advanced References:

Additional learning resources (recent reviews and journal articles) are detailed on the Canvas site for this unit.

Safety and protective equipment

1. Laboratory Gown - Rear fastening 100% cotton or polyester/cotton mix
2. Safety eye protection glasses - selected and used in accordance with Australian Safety Standards
3. Fully enclosed non-slip shoes

Risk Assessment Statement

This unit includes a laboratory component. In order that you become proficient in necessary practical skills, you will be trained in the handling of equipment, materials and specimens normally associated with this discipline. You are required to view a Health & Safety Induction video and complete an online health and safety quiz prior to being permitted into the laboratory, to access please follow this link Health & Safety Induction. A passing score of 10/10 is required and will be checked prior to entry to the first laboratory session. You may repeat the quiz until this score is achieved. You are also referred to the Faculty of Health's Health & Safety Web Site for further information.

If you have an underlying health condition you are encouraged to consult the lecturer in charge of the unit, as you may be required to take additional precautions on occasions.

Course Learning Outcomes

LS40 Bachelor of Biomedical Science

1. Critically review, analyse and synthesise foundational knowledge in a broad range of biomedical discipline areas and in depth theoretical, technical and practical knowledge in specialised discipline areas.
   Relates to: Problem Solving Task, Practical Reports, Examination
2. Demonstrate the cognitive skills required to find solutions to scientific problems.
   Relates to: Problem Solving Task, Practical Reports, Examination
3. Contribute effectively to biomedical projects, either as an individual or as a member of a team, by demonstrating professional behaviour and participating in continuous learning.
   Relates to: Problem Solving Task
4. Apply knowledge and skills to rapidly source, critically analyse and communicate biomedical science information using appropriate technologies.
   Relates to: Practical Reports